Differential progression of brain atrophy in Parkinson's disease with and without visual hallucinations
Identifieur interne : 000A65 ( Main/Corpus ); précédent : 000A64; suivant : 000A66Differential progression of brain atrophy in Parkinson's disease with and without visual hallucinations
Auteurs : Naroa Ibarretxe-Bilbao ; Blanca Ramirez-Ruiz ; Carme Junque ; Maria Jose Marti ; Francesc Valldeoriola ; Nuria Bargallo ; Silvia Juanes ; Eduardo TolosaSource :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2010-06.
Abstract
Objective To determine the course of cognitive deficits and the regional progression of brain atrophy in patients with Parkinson's disease (PD) with and without visual hallucinations (VH). Methods The authors performed MRI and neuropsychological assessment at entry to the study and at follow-up (mean±SD=29.91±5.74 months) in a sample of initially non-demented 12 PD patients with VH, 14 PD patients without VH and 12 healthy controls (HC). Grey-matter changes over time were assessed by means of voxel-based morphometry (VBM) and cognitive changes by an extensive neuropsychological battery. Results At follow-up, 75% of patients with VH developed dementia. The greatest decline was observed in verbal memory, semantic fluency, language comprehension and visuoperceptive functions. None of the patients without VH met criteria for dementia and did not show any worsening in cognitive functions over time. Patients with VH showed widespread limbic, paralimbic and neocortical grey-matter loss, whereas in the PD without VH group, grey-matter loss was restricted to a small region in the frontal cortex and cerebellum. The authors also found significant correlations between the changes in several cognitive functions and grey-matter loss over time in PD patients with VH. Conclusion The presence of VH in PD determines a different cognitive outcome and a different pattern of progressive brain atrophy. PD patients with VH, unlike PD without VH, frequently develop dementia and show a widespread atrophy involving limbic, paralimbic and neocortical areas.
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DOI: 10.1136/jnnp.2009.179655
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Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Ramirez Ruiz, Blanca" sort="Ramirez Ruiz, Blanca" uniqKey="Ramirez Ruiz B" first="Blanca" last="Ramirez-Ruiz">Blanca Ramirez-Ruiz</name><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name><affiliation><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: cjunque@ub.edu</mods:affiliation></affiliation></author><author><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="Maria Jose" last="Marti">Maria Jose Marti</name><affiliation><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name><affiliation><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Bargallo, Nuria" sort="Bargallo, Nuria" uniqKey="Bargallo N" first="Nuria" last="Bargallo">Nuria Bargallo</name><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre de Diagnòstic per la Imatge Hospital Clínic de Barcelona (CDIC), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Juanes, Silvia" sort="Juanes, Silvia" uniqKey="Juanes S" first="Silvia" last="Juanes">Silvia Juanes</name><affiliation><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><affiliation><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2010-06">2010-06</date><biblScope unit="volume">81</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="650">650</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">CFDB51D45D5003336E542F3B6881650885CF1F76</idno><idno type="DOI">10.1136/jnnp.2009.179655</idno><idno type="href">jnnp-81-650.pdf</idno><idno type="ArticleID">jnnp179655</idno><idno type="PMID">19965847</idno><idno type="local">jnnp;81/6/650</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objective To determine the course of cognitive deficits and the regional progression of brain atrophy in patients with Parkinson's disease (PD) with and without visual hallucinations (VH). Methods The authors performed MRI and neuropsychological assessment at entry to the study and at follow-up (mean±SD=29.91±5.74 months) in a sample of initially non-demented 12 PD patients with VH, 14 PD patients without VH and 12 healthy controls (HC). Grey-matter changes over time were assessed by means of voxel-based morphometry (VBM) and cognitive changes by an extensive neuropsychological battery. Results At follow-up, 75% of patients with VH developed dementia. The greatest decline was observed in verbal memory, semantic fluency, language comprehension and visuoperceptive functions. None of the patients without VH met criteria for dementia and did not show any worsening in cognitive functions over time. Patients with VH showed widespread limbic, paralimbic and neocortical grey-matter loss, whereas in the PD without VH group, grey-matter loss was restricted to a small region in the frontal cortex and cerebellum. The authors also found significant correlations between the changes in several cognitive functions and grey-matter loss over time in PD patients with VH. Conclusion The presence of VH in PD determines a different cognitive outcome and a different pattern of progressive brain atrophy. PD patients with VH, unlike PD without VH, frequently develop dementia and show a widespread atrophy involving limbic, paralimbic and neocortical areas.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>Naroa Ibarretxe-Bilbao</name><affiliations><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Blanca Ramirez-Ruiz</name><affiliations><json:string>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Carme Junque</name><affiliations><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</json:string><json:string>E-mail: cjunque@ub.edu</json:string></affiliations></json:item><json:item><name>Maria Jose Marti</name><affiliations><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Francesc Valldeoriola</name><affiliations><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Nuria Bargallo</name><affiliations><json:string>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Centre de Diagnòstic per la Imatge Hospital Clínic de Barcelona (CDIC), Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Silvia Juanes</name><affiliations><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Eduardo Tolosa</name><affiliations><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</json:string><json:string>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Research paper</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MRI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hallucinations</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>longitudinal</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>neuropsychology</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Objective To determine the course of cognitive deficits and the regional progression of brain atrophy in patients with Parkinson's disease (PD) with and without visual hallucinations (VH). Methods The authors performed MRI and neuropsychological assessment at entry to the study and at follow-up (mean±SD=29.91±5.74 months) in a sample of initially non-demented 12 PD patients with VH, 14 PD patients without VH and 12 healthy controls (HC). Grey-matter changes over time were assessed by means of voxel-based morphometry (VBM) and cognitive changes by an extensive neuropsychological battery. Results At follow-up, 75% of patients with VH developed dementia. The greatest decline was observed in verbal memory, semantic fluency, language comprehension and visuoperceptive functions. None of the patients without VH met criteria for dementia and did not show any worsening in cognitive functions over time. Patients with VH showed widespread limbic, paralimbic and neocortical grey-matter loss, whereas in the PD without VH group, grey-matter loss was restricted to a small region in the frontal cortex and cerebellum. The authors also found significant correlations between the changes in several cognitive functions and grey-matter loss over time in PD patients with VH. Conclusion The presence of VH in PD determines a different cognitive outcome and a different pattern of progressive brain atrophy. PD patients with VH, unlike PD without VH, frequently develop dementia and show a widespread atrophy involving limbic, paralimbic and neocortical areas.</abstract><qualityIndicators><score>8.236</score><pdfVersion>1.4</pdfVersion><pdfPageSize>595.147 x 793.567 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>7</keywordCount><abstractCharCount>1556</abstractCharCount><pdfWordCount>5069</pdfWordCount><pdfCharCount>36155</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>228</abstractWordCount></qualityIndicators><title>Differential progression of brain atrophy in Parkinson's disease with and without visual hallucinations</title><pmid><json:string>19965847</json:string></pmid><genre><json:string>research-article</json:string></genre><host><volume>81</volume><pages><first>650</first></pages><issn><json:string>0022-3050</json:string></issn><issue>6</issue><genre></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-330X</json:string></eissn><title>Journal of Neurology, Neurosurgery & Psychiatry</title></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1136/jnnp.2009.179655</json:string></doi><id>CFDB51D45D5003336E542F3B6881650885CF1F76</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/CFDB51D45D5003336E542F3B6881650885CF1F76/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/CFDB51D45D5003336E542F3B6881650885CF1F76/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/CFDB51D45D5003336E542F3B6881650885CF1F76/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Differential progression of brain atrophy in Parkinson's disease with and without visual hallucinations</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>BMJ Publishing Group Ltd</publisher><availability><p>BMJ</p></availability><date>2009-12-03</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Differential progression of brain atrophy in Parkinson's disease with and without visual hallucinations</title><author><persName><forename type="first">Naroa</forename><surname>Ibarretxe-Bilbao</surname></persName><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Blanca</forename><surname>Ramirez-Ruiz</surname></persName><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation></author><author corresp="yes"><persName><forename type="first">Carme</forename><surname>Junque</surname></persName><email>cjunque@ub.edu</email><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Maria Jose</forename><surname>Marti</surname></persName><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Francesc</forename><surname>Valldeoriola</surname></persName><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Nuria</forename><surname>Bargallo</surname></persName><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Centre de Diagnòstic per la Imatge Hospital Clínic de Barcelona (CDIC), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Silvia</forename><surname>Juanes</surname></persName><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Eduardo</forename><surname>Tolosa</surname></persName><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation></author></analytic><monogr><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="pISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2010-06"></date><biblScope unit="volume">81</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="650">650</biblScope></imprint></monogr><idno type="istex">CFDB51D45D5003336E542F3B6881650885CF1F76</idno><idno type="DOI">10.1136/jnnp.2009.179655</idno><idno type="href">jnnp-81-650.pdf</idno><idno type="ArticleID">jnnp179655</idno><idno type="PMID">19965847</idno><idno type="local">jnnp;81/6/650</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009-12-03</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Objective To determine the course of cognitive deficits and the regional progression of brain atrophy in patients with Parkinson's disease (PD) with and without visual hallucinations (VH). Methods The authors performed MRI and neuropsychological assessment at entry to the study and at follow-up (mean±SD=29.91±5.74 months) in a sample of initially non-demented 12 PD patients with VH, 14 PD patients without VH and 12 healthy controls (HC). Grey-matter changes over time were assessed by means of voxel-based morphometry (VBM) and cognitive changes by an extensive neuropsychological battery. Results At follow-up, 75% of patients with VH developed dementia. The greatest decline was observed in verbal memory, semantic fluency, language comprehension and visuoperceptive functions. None of the patients without VH met criteria for dementia and did not show any worsening in cognitive functions over time. Patients with VH showed widespread limbic, paralimbic and neocortical grey-matter loss, whereas in the PD without VH group, grey-matter loss was restricted to a small region in the frontal cortex and cerebellum. The authors also found significant correlations between the changes in several cognitive functions and grey-matter loss over time in PD patients with VH. Conclusion The presence of VH in PD determines a different cognitive outcome and a different pattern of progressive brain atrophy. PD patients with VH, unlike PD without VH, frequently develop dementia and show a widespread atrophy involving limbic, paralimbic and neocortical areas.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>dementia</term></item><item><term>MRI</term></item><item><term>hallucinations</term></item><item><term>longitudinal</term></item><item><term>neuropsychology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-12-03">Created</change><change when="2010-06">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/CFDB51D45D5003336E542F3B6881650885CF1F76/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">jnnp</journal-id><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-id journal-id-type="publisher-id">jnnp</journal-id><journal-title>Journal of Neurology, Neurosurgery & Psychiatry</journal-title><abbrev-journal-title abbrev-type="publisher">J Neurol Neurosurg Psychiatry</abbrev-journal-title><abbrev-journal-title>J Neurol Neurosurg Psychiatry</abbrev-journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">jnnp179655</article-id><article-id pub-id-type="doi">10.1136/jnnp.2009.179655</article-id><article-id pub-id-type="other">jnnp;81/6/650</article-id><article-id pub-id-type="other">jnnp;jnnp.2009.179655</article-id><article-id pub-id-type="pmid">19965847</article-id><article-id pub-id-type="other">650</article-id><article-id pub-id-type="other">jnnp.2009.179655</article-id><article-categories><subj-group subj-group-type="heading"><subject content-type="original">Research paper</subject></subj-group></article-categories><title-group><article-title>Differential progression of brain atrophy in Parkinson's disease with and without visual hallucinations</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ibarretxe-Bilbao</surname><given-names>Naroa</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Ramirez-Ruiz</surname><given-names>Blanca</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Junque</surname><given-names>Carme</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Marti</surname><given-names>Maria Jose</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Valldeoriola</surname><given-names>Francesc</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bargallo</surname><given-names>Nuria</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Juanes</surname><given-names>Silvia</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tolosa</surname><given-names>Eduardo</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff4">4</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</aff><aff id="aff2"><label>2</label>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</aff><aff id="aff3"><label>3</label>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</aff><aff id="aff4"><label>4</label>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</aff><aff id="aff5"><label>5</label>Centre de Diagnòstic per la Imatge Hospital Clínic de Barcelona (CDIC), Hospital Clínic de Barcelona, Barcelona, Spain</aff><author-notes><corresp><label>Correspondence to</label> Professor Carme Junque, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Casanova 143, Barcelona 08036, Spain; <email>cjunque@ub.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>6</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>3</day><month>12</month><year>2009</year></pub-date><volume>81</volume><volume-id pub-id-type="other">81</volume-id><volume-id pub-id-type="other">81</volume-id><issue>6</issue><issue-id pub-id-type="other">jnnp;81/6</issue-id><issue-id pub-id-type="other">6</issue-id><issue-id pub-id-type="other">81/6</issue-id><fpage>650</fpage><history><date date-type="received"><day>1</day><month>4</month><year>2009</year></date><date date-type="rev-recd"><day>21</day><month>9</month><year>2009</year></date><date date-type="accepted"><day>19</day><month>10</month><year>2009</year></date></history><permissions><copyright-statement>© 2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</copyright-statement><copyright-year>2010</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="jnnp-81-650.pdf"></self-uri><abstract><sec><title>Objective</title><p>To determine the course of cognitive deficits and the regional progression of brain atrophy in patients with Parkinson's disease (PD) with and without visual hallucinations (VH).</p></sec><sec><title>Methods</title><p>The authors performed MRI and neuropsychological assessment at entry to the study and at follow-up (mean±SD=29.91±5.74 months) in a sample of initially non-demented 12 PD patients with VH, 14 PD patients without VH and 12 healthy controls (HC). Grey-matter changes over time were assessed by means of voxel-based morphometry (VBM) and cognitive changes by an extensive neuropsychological battery.</p></sec><sec><title>Results</title><p>At follow-up, 75% of patients with VH developed dementia. The greatest decline was observed in verbal memory, semantic fluency, language comprehension and visuoperceptive functions. None of the patients without VH met criteria for dementia and did not show any worsening in cognitive functions over time. Patients with VH showed widespread limbic, paralimbic and neocortical grey-matter loss, whereas in the PD without VH group, grey-matter loss was restricted to a small region in the frontal cortex and cerebellum. The authors also found significant correlations between the changes in several cognitive functions and grey-matter loss over time in PD patients with VH.</p></sec><sec><title>Conclusion</title><p>The presence of VH in PD determines a different cognitive outcome and a different pattern of progressive brain atrophy. PD patients with VH, unlike PD without VH, frequently develop dementia and show a widespread atrophy involving limbic, paralimbic and neocortical areas.</p></sec></abstract><kwd-group><kwd>Parkinson's disease</kwd><kwd>dementia</kwd><kwd>MRI</kwd><kwd>hallucinations</kwd><kwd>longitudinal</kwd><kwd>neuropsychology</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Differential progression of brain atrophy in Parkinson's disease with and without visual hallucinations</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Differential progression of brain atrophy in Parkinson's disease with and without visual hallucinations</title></titleInfo><name type="personal"><namePart type="given">Naroa</namePart><namePart type="family">Ibarretxe-Bilbao</namePart><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Blanca</namePart><namePart type="family">Ramirez-Ruiz</namePart><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Carme</namePart><namePart type="family">Junque</namePart><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><affiliation>E-mail: cjunque@ub.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria Jose</namePart><namePart type="family">Marti</namePart><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesc</namePart><namePart type="family">Valldeoriola</namePart><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nuria</namePart><namePart type="family">Bargallo</namePart><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Centre de Diagnòstic per la Imatge Hospital Clínic de Barcelona (CDIC), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Silvia</namePart><namePart type="family">Juanes</namePart><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eduardo</namePart><namePart type="family">Tolosa</namePart><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</affiliation><affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2010-06</dateIssued><dateCreated encoding="w3cdtf">2009-12-03</dateCreated><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Objective To determine the course of cognitive deficits and the regional progression of brain atrophy in patients with Parkinson's disease (PD) with and without visual hallucinations (VH). Methods The authors performed MRI and neuropsychological assessment at entry to the study and at follow-up (mean±SD=29.91±5.74 months) in a sample of initially non-demented 12 PD patients with VH, 14 PD patients without VH and 12 healthy controls (HC). Grey-matter changes over time were assessed by means of voxel-based morphometry (VBM) and cognitive changes by an extensive neuropsychological battery. Results At follow-up, 75% of patients with VH developed dementia. The greatest decline was observed in verbal memory, semantic fluency, language comprehension and visuoperceptive functions. None of the patients without VH met criteria for dementia and did not show any worsening in cognitive functions over time. Patients with VH showed widespread limbic, paralimbic and neocortical grey-matter loss, whereas in the PD without VH group, grey-matter loss was restricted to a small region in the frontal cortex and cerebellum. The authors also found significant correlations between the changes in several cognitive functions and grey-matter loss over time in PD patients with VH. Conclusion The presence of VH in PD determines a different cognitive outcome and a different pattern of progressive brain atrophy. PD patients with VH, unlike PD without VH, frequently develop dementia and show a widespread atrophy involving limbic, paralimbic and neocortical areas.</abstract><subject><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>dementia</topic><topic>MRI</topic><topic>hallucinations</topic><topic>longitudinal</topic><topic>neuropsychology</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neurology, Neurosurgery & Psychiatry</title></titleInfo><titleInfo type="abbreviated"><title>J Neurol Neurosurg Psychiatry</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0022-3050</identifier><identifier type="eISSN">1468-330X</identifier><identifier type="PublisherID">jnnp</identifier><identifier type="PublisherID-hwp">jnnp</identifier><identifier type="PublisherID-nlm-ta">J Neurol Neurosurg Psychiatry</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>650</start></extent></part></relatedItem><identifier type="istex">CFDB51D45D5003336E542F3B6881650885CF1F76</identifier><identifier type="DOI">10.1136/jnnp.2009.179655</identifier><identifier type="href">jnnp-81-650.pdf</identifier><identifier type="ArticleID">jnnp179655</identifier><identifier type="PMID">19965847</identifier><identifier type="local">jnnp;81/6/650</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010, Published by the BMJ Publishing Group Limited. 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